Problem: Article: If stress, anxiety and/or depression is negatively impacting your life, then talk with a mental health professional. A psychiatrist, psychologist or counselor can give you insights on your issue and attempt to address the underlying cause of your imbalance. Mental health professionals sometimes use drugless techniques and therapies, such as psychotherapy and cognitive-behavioral therapy. Whether psychotherapy or cognitive-behavioral therapy can balance brain chemicals is unclear, but both therapies have a track record of success dealing with depression and anxiety — although it often takes many weeks or months.  Psychotherapy is a type of counseling that addresses the emotional response to mental illnesses. Patients are encouraged to talk through strategies for understanding and dealing with their disorder. Cognitive-behavioral therapy involves patients learning to recognize and change their thought patterns and behaviors that lead to troublesome feelings. Unfortunately, there are no blood tests that can directly measure neurotransmitter levels in the brain; however, an imbalance of hormones (such as insulin or thyroid hormone) can be detected by blood tests and may be related to altered mood. Other measurable components in the blood that have been linked to depression include very high levels of copper, too much lead and low levels of folate. The neurotransmitters serotonin, dopamine and norepinephrine are closely tied to depression and anxiety, so most antidepressant drugs are designed to affect these chemicals. For depression, doctors typically start by prescribing a selective serotonin reuptake inhibitor (SSRI) because these drugs are relatively safer and cause fewer serious side effects than other types of antidepressants. SSRIs relieve symptoms by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain, which leaves more serotonin available to improve mood.  SSRIs include fluoxetine (Prozac, Selfemra), paroxetine (Paxil, Pexeva), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro). SSRIs are considered relatively effective for treating all anxiety disorders, including depression and obsessive-compulsive disorder (OCD). Common side effects of SSRIs include insomnia (inability to get to sleep), sexual dysfunction and weight gain. Although SSRIs are often given to patients with an assumed chemical imbalance of serotonin, their use sometimes triggers "serotonin syndrome" — dangerously high levels of serotonin. Symptoms of Serotonin Syndrome include flushing of the skin, elevated heart rate, elevated temperature, elevated blood pressure, vomiting, and diarrhea.  If you are having these symptoms and are on an SSRI then consult you doctor immediately. If you are having problems with side effects from SSRIs talk to your family doctor or psychiatrist.  There are different profiles for each medication and each have different advantages and disadvantages.  You doctor will know best which medication to prescribe. Serotonin-norepinephrine reuptake inhibitors (SNRIs) are similar to SSRIs, but they have a dual mechanism of action: they increase the levels of both serotonin and norepinephrine by inhibiting their reabsorption into neurons in the brain. SNRI drugs are considered as effective as SSRIs, so they are also considered a first-line treatment that's commonly prescribed by doctors, especially for the treatment of generalized anxiety disorder.  SNRIs include duloxetine (Cymbalta), venlafaxine (Effexor XR), desvenlafaxine (Pristiq, Khedezla) and levomilnacipran (Fetzima). Common side effects of SNRIs include insomnia, stomach upset, excessive sweating, headaches, sexual dysfunction and hypertension (high blood pressure). Some SNRIs like Cymbalta are approved to treat depression in those with chronic pain disorders. A drug like Effexor hand might be used in people with generalized anxiety disorder as well as depression. Taking SNRIs can also trigger an imbalance of serotonin levels in the brain referred to as serotonin syndrome. Benzodiazepines are an older class of drugs still used for short-term management of anxiety. They can be highly effective in promoting relaxation, reducing muscle tension and other physical symptoms associated with anxiety by enhancing the effect of the neurotransmitter GABA. Benzodiazepines are not appropriate for long-term use, however, as there can be serious side effects, such as aggression, cognitive impairment, addiction, and deeper depression. As such, concerns about long-term use of benzodiazepines led many psychiatrists and physicians to favor tricyclic antidepressants before SSRIs and SNRIs came on the market. Tricyclics are relatively effective for treating anxiety because they increase serotonin levels in the brain, but they are also problematic long term. Consequently, tricyclic antidepressants aren't usually prescribed unless you've been on a SSRI and it hasn't worked for you.  Benzodiazepines include alprazolam (Xanax, Niravam), clonazepam (Klonopin), diazepam (Valium, Diastat) and lorazepam (Ativan). Tricyclic antidepressants include imipramine (Tofranil), nortriptyline (Pamelor), amitriptyline, doxepin, trimipramine (Surmontil), desipramine (Norpramin) and protriptyline (Vivactil).  Tricyclic antidepressants have the potential to be cardio-toxic and have to be used in caution in people with heart disease.
Summary: Consult with a mental health professional. Ask your doctor about SSRIs. Consider SNRIs as an alternative. Be cautious with benzodiazepines and tricyclic antidepressants.

Problem: Article: Transfer the filled pastry shell to the hot oven and bake the quiche until the edges look dry and the crust has browned. To tell if it's finished baking, move the pie plate a little. The filling should jiggle just a little in the center and not be completely fluid. If you're concerned that the pastry edges are browning too quickly, cover just the pastry with a pie shield or strips of aluminum foil. Remove the baked quiche from the oven and set it on the stove to cool a little. You can slice the quiche and serve it while it's still slightly warm or at room temperature.  The quiche will finish cooking and set up as it cools. Cover and refrigerate leftover quiche for up to 3 days. To reheat the quiche, warm it in a 300 °F (149 °C) oven for 10 to 15 minutes.
Summary:
Bake the quiche at 350 °F (177 °C) for 30 to 40 minutes. Cool the quiche for at least 20 minutes before serving.