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From the start, you need a strong argument for ending the relationship, so you can make sure you follow through. Get real with yourself and take some time to write out all the reasons this relationship is toxic and needs to end. One of the most important reasons to leave a toxic relationship is because you deserve better. In addition, the relationship may be preventing you from growing, isolating you from others, or becoming borderline or full-on abusive. Go over what you want to say to the person beforehand. This will help you to appear more confident when you have the talk.  You can rehearse in front of a mirror or with a friend. Rehearsing can help you feel more confident when you speak, but keep in mind the conversation may go differently than you rehearsed. Give the person advance notice that you want to have a conversation and ask them when they are available to talk. Depending on how safe you feel, consider reaching out in person, over the phone, or via text. You might say, "Hey, I need to talk to you about something important. Do you have time to get together?" Have a face-to-face discussion with the person, if possible. Set the location based on how you expect the conversation to go. For example, if the person is likely to become angry, have the conversation in a public place. If this is an abusive relationship, have the talk by phone or through video call for your safety. Be direct about what's not working in the relationship and your decision to end it.  You might say something like, “I don't think we're good together. We breakup and makeup all the time and I have started to alienate other people who are close to me. I want to end it.” Another option is to say something like, "Our relationship is not working for me. I've thought it through, and I want to end it." There's a good chance the other person will have quite a mouthful to say. Listen to what they have to say as long as their response is free of insults or threats.  If they try to convince you not to end it or some other tactic, simply restate your decision. Be as clear and concise as possible. If they become angry or argumentative, say “I didn't come here to argue. I'm leaving. Please don't follow me.”
Remind yourself why the relationship must end. Rehearse the conversation. Let the person know you want to talk. Choose where to have the talk. Be clear and straightforward about what you want. Hear the other person out.