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The thread count of a sheet affects its softness. Many people believe a higher thread count means softer sheets. However, many manufacturer's exaggerate thread count, so this is not necessarily always the case. In general, a thread count of over 200 is recommended for comfort. Anything above 800 is probably unnecessary. You can identify fabricated thread counts by thread type. Thread that is 2-ply is often twisted around itself to create a higher thread count. However, as the thread is of less high quality, this does not mean the sheets will be softer. Be wary of sheets made from 2-ply thread. Most sheets are finished with a chemical process to keep them from wrinkling. If you're not adverse to chemical-based products, wrinkle free sheets can require a lot less upkeep. However, if you're wary about chemicals, look for sheets labeled as organic. If you're buying a patterned sheet, it may use a lot of dye. Your sheets may feel stiff and uncomfortable if you don't wash them a few times before use. If you have a sensitivity to any type of dye, avoid getting sheets that contain that product. Most varieties of sheets come in many different colors and patterns. Ideally, you'll want colors that match the scheme of your room. For example, if you have a room with blue wallpaper, you may want to go with blue sheets. Keep in mind dark colors hide stains better. If you're buying sheets for a very young child, who may have an accident in the bed, go for darker sheets.
Pick an appropriate thread count. Pay attention to finish. Look at what types of dyes are used. Pick the right color.