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Avoid yarn that gets tangled. Find your lost end. Do something about your lumpy thread. Trouble-shoot your handspinning.
Sometimes your yarn gets tangled between the bobbin and the flyer. Basically this means that your treadling isn't even (which happens a lot with first time spinners!). Break off the yarn, hook it back up, and start over again. This can also happen because the bobbin is too full, which causes the yarn to spill over the edges of the bobbin and tangle around the shaft. Empty the bobbin as you would normally and start fresh. Sometimes when you're spinning you lose the end. Don't fret! Roll your bobbin around a few times. Often the end is under the last hook that it was over.   Try using a piece of tape to see if you can pull up the loose end. This solution works about half the time. Otherwise, pick the most likely end and pull enough yarn for a new leader so you can start again. If your yarn is lumpy and bumpy it means that you aren't spinning it consistently. You might be pulling out too much fiber. If so, what you need to work on is getting into a consistent rhythm for spinning. Some of the same problems happen in handspinning that happen with a spinning wheel. Sometimes there is a different way of fixing it as opposed to a spinning wheel (for example, you don't have the flyer and the bobbin and so those types of tangles aren't typical).   Spindle gets away from you. If your spindle gets away from you and the twists runs up into the fiber mass, stop your spindle and untwist your fiber mass. Then, start the drafting again. This is a very common occurrence for beginners. If you have thick and thin spots in your yarn (known as slubs), you can do something like keep them and have a novelty yarn (good for knitting scarves). Otherwise you can remove the slubs by pinching the yarn with your hands on either side of the slub and untwisting until the fibers draft out a little. Over-twisted yarn is a common beginner's problem. You can tell your yarn is over-twisted if you have a thick strand that feels very hard and dense. The strand can kink back on itself when you relax your tension. To fix this, loosen some of the extra twist by drafting out more fibers.