If you're going to a social event, it's okay to practice. Many people feel more relaxed if they give themselves time to prepare conversation starters ahead of time.  You can write down a list of potential conversation starters. You could, for example, talk about an assignment if you're making conversation in class. You could even practice in the mirror ahead of time. While it may sound a little silly, if you're often nervous about starting a conversation this can be helpful. When trying to begin small talk, scan the room. See if there's anyone not talking to someone. Try to make brief eye contact and offer a smile. You can then approach this person to begin a conversation. When you approach the person, try a simple greeting. You can say something like, "Hi" or "How are you?" It can be hard to strike up a conversation with a stranger. However, there are many ways to initially engage with someone. Use a quality conversation starter to get the ball rolling.  Conversation starters should be personal and reflect genuine interest. Instead of commenting on the weather, mention something the other party can relate to. You should also bring up something of genuine interest to you. It's hard to feign interest, and people want to converse with those who are generally invested in them. For example, you're at a party at a friend's place. You see a casual acquaintance there who you know just took the bar exam. You're interested in law, as your brother is an attorney. You can say something like, "Hey, how did the bar exam go?" This is a great way to begin a conversation. If you're very nervous, you can look for something nearby to discuss. While this is less personal, it can work in a bind. You can, for example, comment on a painting on the wall.

Summary:
Practice ahead of time if you're prone to anxiety. Smile and make initial eye contact. Find a good conversation starter.