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It is important to have a single, large diaper bag that can hold everything for both of the twins instead of carrying separate bags for each. Having a single bag for both babies will make life easier and reduce your chances of forgetting something important. You already have two children to keep track of, why make it harder with two diaper bags to keep track of as well?   The set-up of the diaper bag is more of a personal choice. Some parents like to have diaper bags with lots of separate compartments for things like wipes or bottles, while other parents are content with something that has one large compartment and maybe a pocket or two. The diaper bag needs strong handles or straps that can support the weight of its contents. The handles or straps also need to be padded so they are comfortable when the parent has to carry it for an extended period of time. Usually parents have a general idea of how often their babies will need to have a fresh diaper and they can use this information to calculate how many diapers to take on an outing.  However, the babies might have off days, and use fewer or more diapers than expected.  A good general rule to follow is to pack one diaper per child, for every hour of the outing, plus a few extras just in case. Make sure to replace the diapers after each outing, so you have the same number of diapers each time. There's nothing worse than a diaper bag with no diapers! Even though you have two babies, you only need to include one large packet of wipes. This ensures that the wipes do not become dried out before you get to the end of the packet. Something that many parents forget to include in their diaper bags is plastic bags. These have many uses, including:  To store dirty diapers if you have nowhere to dispose of them at the moment. To hold any dirty clothes and keep them separate from everything else until they can be properly taken care of at home. To store any sterilized items like spoons or bowls. Keep approximately ten plastic zip bags in the diaper bag at any given time. Carrying a small first aid kit that contains a few essentials (for both parent and babies) is always a good idea.  Include the most necessary first aid items, such as adhesive bandages, children's painkillers like Tylenol or Advil and anti-rash cream. You should also keep a small scissors in the first aid kit - this can come in useful when you least expect it!
Choose the right diaper bag. Pack a large supply of diapers. Include one large packet of wipes. Consider packing some plastic zip bags. Carry a first aid kit in the diaper bag.