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Not all companies have the same goals even if they are looking to fill the same position.  Finding a company that agrees with your own personal values can make sure that you will be comfortable working there.  This can also help by assuaging any fears that your new employer might have regarding how well you will fit their culture.  Try looking online at the company's website to get a better feel for their culture. Ask any contacts you might have what the culture is like at the place you are investigating. Looking up reviews of the company can give you a good idea of how they interact with either past employees or customers. Most every employer will have some kind of social networking presences that you can examine. When searching for a position after being self-employed, it can be a good idea to focus the search on companies that have a unique need for your skill set.  Presenting yourself as someone capable of filling a specific need that an employer might have can give you the advantage and allow your application to be taken into consideration. Keep this in mind when crafting your resume and objective. If they need a team leader, you can emphasize your ability to self-start and keep yourself on task, which will translate nicely. Finding a new position and successfully obtaining it using large on-line databases or other traditional job search methods might work.  However, these methods can be difficult for a previously self employed person to find success with.  Instead, networking is the best option for finding an open position and getting an interview after being self employed.  Make your professional goals known to those you meet.  You never know who might end up helping you obtain a new position. Finding a friend that already works in a field you're interested is a great way to make contacts in that field.  You might also be able to make additional contacts through people you already know. Talk about your skills and accomplishments as well as anything you are currently working on. Keep track of the names and faces of any contacts you make. A great way to demonstrate your skill and personal passion for whatever position you might be seeking is to start a blog.  By creating quality and engaging content about your chosen field of interest, you can demonstrate your skills, knowledge, and ability to a potential employer.  Start posting to your blog regularly and work to build up an impressive display of your professional value.  You might want to turn your blog into your resume by including a neat presentation of your qualifications and contact information. Make sure your blog is sending the right message.  Keep your content, tone and presentation clean and professional. Seek out professional associations, conferences, and conventions that work in the field you are trying to gain employment with.  Attending these meetings will allow you to learn new skills and meet new people, giving you fresh leads on open positions to pursue.
Find a company that has the right culture. Look for companies that can benefit from your skills. Network. Start a blog. Attend professional gatherings.