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If the manufacturer's label is still attached to a plush toy, check it before washing the toy. There may be specific instructions on how to wash the toy. Some toys, for example, may not be machine washable or might require a special type of cleaner. If there's no label, google the type of toy. If it's a popular brand, you may be able to find manufacturer's instructions online. Most plush toys can be safely washed in the washing machine, particularly cotton and polyester blends. Wash them with your regular clothing on a gentle cycle. Alternatively, you can also do a load of just plush toys.  If the toy is very dirty or soiled, sprinkle some baking soda on it before putting in the machine. Then, add a cap full of white vinegar to the washing machine during the rinse cycle. If you cannot find a label, it is relatively safe to assume that the toy is machine washable. Most plush toys are. Put the toys through an extra rinse cycle to ensure that all detergent comes out. Unless they are labeled "felted," wool toys cannot go into the washing machine. For these toys, try to spot clean stains. Dab the stain out using a mild soap and a wet cloth. Let the toys air dry. If the wool toys are very dirty, you can try hand washing them in the bathtub with a wool soap. Do not dry wool toys in the drying machine, however, as this can damage them. Lay wool toys on a sunny windowsill instead. If your toy is not wool, it can be put in the dryer. You can put the toy in a pillowcase beforehand to protect it as it in the dryer. Dry on high for 15 minutes. If the toys are still a little wet, let them air dry. Wool toys should be air dried in a warm spot.

Summary:
Check the label. Wash toys in the washing machine unless otherwise directed. Clean wool toys by hand. Dry plush toys in the dryer.