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See if your friend is acting negatively towards you. Look out for how often you are communicating. Ask yourself how you learn about new things in your friend's life. See if your friend ignores you for time with others. Think about how it feels being around your friend.
If your friend is regularly insulting or belittling you, or starting arguments over all kinds of things, they are not being a good friend. If your friend is doing this, confront them, and ask them to stop. If your friend doesn't, that is not a good sign.  Types of insults can include teasing, sarcasm, and cynicism, comments that may sound like jokes, but are meant to hurt you. Some insults are more subtle, like backhanded compliments (complimenting you for negative things) or guilt-tripping (where your friend blames you for their distresses and problems). In many cases, your friend may try to pass these insults off as humor, and ridicule you for taking them personally. It is possible that your friend doesn't know they are insulting you. If you are concerned, confront them. If your friend didn't know, they may apologize right away. If your friend doesn't like you, they probably aren't making much of an effort to stay in touch. This means not just talking, but emails, texting, or any other form of communication. If you and your friend aren't talking very much, it is hard to say that you are still really friends.  This reduced communication can refer to frequency or length. You may not talk as often as you used to. Or, if you do talk, your conversations are now very short, and you find that you don't have much to talk about. You can also see this if you are the one making an effort at communication. Friendship takes effort. If you are the only one trying to stay in touch, then your friend is probably not interested. Along with not talking much, chances are your friend won't have been keeping you up to date with changes in their life. Friendship takes effort, and you shouldn't learn new things about your friend only through other people or social media. If you try to make plans, and your friend says they are too busy but is later out with other friends during that time, that would be a sign of rejection.  People change, have new interests, and new friends. If your friend appears to be doing other things with new people, then those new people probably fit in better with their new interests.  If your friend is not spending more time with others, but becoming withdrawn towards everyone,  that could be a sign of more serious issues, like depression. If this might be the case, gather others, and as a group encourage your friend to seek help. If your friendship is turning sour, your meetings will be tense, and you may feel anxious or uncomfortable in each other's presence. There may be a larger concern that you are not dealing with, or maybe you two have grown apart.