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Provide plenty of praise for trying this new thing, even when they're not sick. Try getting a fun box of tissues with interesting patterns or designs on it to encourage your child to use them more often.  Try different varieties of tissue paper, and have your child tell you which one they prefer. Some children may be extremely sensitive to texture or scents that you may not even notice. Having a tissue paper that the child doesn't mind will help this teaching process tremendously. Make sure you have plenty of the kind of tissue paper your child prefers ready when they're sick. When your child is sick, it's likely that he'll resist doing anything new. They will likely want to be left alone, or cuddled, so be gentle. When you have a cold, you can use this opportunity to model using a tissue to blow your own nose, encouraging your child to imitate.  Siblings can also serve as role models for your child as they learns how to blow their nose. Younger siblings might be distinguished by the fact that they aren't old enough to blow their own nose. Often, this comparison has a good deal of attraction for an older sibling. Explicitly point out the steps of blowing the nose, as you do them or as others do. Narrate the process as you go through the steps. They might need to be reminded to close their mouth.  Keep a gentle, light tone of voice when teaching this new skill. If your child wants to hold the tissue themselves, let them! While it may be easier for the child to learn simply by blowing into a tissue you hold, some children may prefer to be in charge of their own tissue. Consider using a humidifier or saline spray to help loosen the mucus if your child is struggling to blow their nose while sick. This may mean that you go through more tissues than you'd like, but teaching the routine of throwing the tissue away will benefit you, and your child, in the long run.  Sometimes the routine of throwing the tissue into the trash can will be a fun incentive for the child in itself. Provide plenty of praise for each tissue that goes from tissue box, to nose, to trash. Always have a trash bin close by as you are teaching this process. If you don't actually have a trash bin so close at hand, improvise by finding another receptacle (such as a plastic container, or an empty bowl) that can function as a temporary trash location until you can move it.
Practice holding a tissue to your child's nose. Point out when yourself or other adults use a tissue to blow their noses. Help your child blow their nose when they're sick by holding the tissue to their nose and telling them to blow. Teach your child to throw away the tissue immediately after they finish blowing.