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Evolve the Necrosis symptom. Evolve the Genetic Reshuffle ability. Evolve Genetic Reshuffle 2 when the cure reaches 25%. Wait for all countries to be infected. Evolve Total Organ Failure. Evolve Dysentery. Evolve Hemorrhagic  Shock. Wait while the world finishes getting infected and killed off.
This symptom will start killing off the hosts, but not too quickly as to end your game. it will also boost your infectivity. This will drop the progress of the cure back a few percentage points. The cure will move quickly towards the end, so you'll want to set it back if it reaches 25% or so before you move on to the final few steps. If you are running low on DNA points, you can skip Genetic Reshuffle 2. You should never need Genetic Shuffle 3. If you haven't yet, you'll want to wait until every country is infected before you turn your disease into a killing machine. When the last country is infected, wait until it has about 10,000-15,000 people infected before moving on. Make sure your last infected country already has 10,000-15,000 people infected before you evolve this symptom. This is going to start killing people off very quickly. This will help ensure that the disease continues to spread as it is killing people. You'll need to have either Diarrhea or Insanity in order to get Dysentery. This symptom will increase the lethality of your disease as you rush towards the end. If you were successful, the entire world should be infected shortly, with death catching up soon after. You can speed things up by getting more symptoms, or evolve Genetic Reshuffle to slow the cure if necessary.