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If you want a handkerchief that you can use to blow your nose and wipe your face, cotton is the way to go. You can choose from many different types of print or solid cotton fabric to create your handkerchief. Cotton is also the most inexpensive option.  Try choosing cotton fabric in seasonal or holiday prints to make festive handkerchiefs to use throughout the year, such as 4 leaf clover fabric for St. Patrick’s day, leaf print fabric for fall, or red and green fabric for Christmas. Pick cotton fabrics that will coordinate with your clothing, such as pink fabric to match a pink dress, or yellow fabric to complement a purple suit. Decorative handkerchiefs are often made from lightweight and/or delicate fabrics. If you want to create a handkerchief that will look good as an accessory or as a decorative piece, then look into lightweight and sheer fabrics, such as:  Silk Chiffon Light muslin Satin
Choose cotton for a functional handkerchief. Opt for a specialty fabric for a delicate design.