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Try Linaclotide to help soften your stool. Consider Lubiprostone if you’re a woman with severe symptoms. Consult your doctor about antidepressants to manage pain.
Talk to your doctor about Linaclotide to increase available fluids in your small intestine. This will help your bowel movements be more regular and decrease constipation-related intestinal pain.  Narcotic pain relievers such as Codeine and Hydrocodone can cause constipation. If you need pain relievers like these, talk to your doctor about finding a stool softener such as Linaclotide to help manage your constipation. Linaclotide has the potential to cause diarrhea, but taking it about an hour before eating usually helps. Talk to your doctor about Lubiprostone if you’re a woman who has seen no improvement in your IBS-C symptoms with lifestyle changes or other medications. Lubiprostone can help your intestines release more fluid to ease constipation. Lubiprostone is only approved for female IBS-C sufferers with severe symptoms who haven’t responded favorably with other treatment. Ask your doctor if serotonin reuptake inhibitors (SSRIs) might be a good fit for your IBS-C symptoms. SSRIs can reduce your perception of IBS-C-related intestinal pain and even ease constipation.  It’s not uncommon for chronic health conditions like IBS to cause depression. SSRIs can help alleviate some anxiety and depression symptoms if you’re struggling with those, as well. Note that tricyclic antidepressants are not recommended for people with IBS-C, as they can cause diarrhea.