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Use hot, clean water, making sure all the soap is gone. Soap left in the loofah could begin to smell. Put it in a place with good circulation so it can dry completely. Drying it out will prevent bacteria from forming inside the loofah. Store your loofah on a hook outside of the shower.  Placing it near a vent or fan can also help it dry out quickly. Since many bathrooms stay humid, you might want to dry the loofah in a different room. You can run it through a hot wash cycle with your towels, run it through the dishwasher, microwave it for 30 seconds, or boil it in hot water for several minutes to kill any bacteria that might be growing. No matter what method you use, do it at least once a week to make sure the loofah stays healthy for use.  Dermatologists have recently found that loofahs tend to harbor more bacteria than previously thought. That's why it's important to sanitize your loofah often.  The same holds true for plastic bath poufs. Even though they aren't made from natural materials, they can still harbor bacteria. After this much time the loofah will be starting to fall apart from use and runs through the washer or boiling water. If you haven't been sanitizing your loofah, it's no longer safe for use after three weeks. Either way, time to get a new loofah.  Many people have recently switched to using washcloths, since they're easier to run through the washer and they last much longer than loofahs. If you decide to stick with loofahs, make sure you dry them properly after each use and replace them frequently to keep your body healthy.
Rinse your loofah after each use. Dry the loofah completely between uses. Sanitize the loofah once a week. Replace your loofah every three weeks.