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Because plexiglass retains dirt and grime, using something like a paper towel or tablecloth will scratch the surface of the plexiglass. Microfiber cloths will not dig into the pores of the plexiglass and will not damage or scratch the plexiglass once the dirt has been blown off the surface. Good alternatives to microfiber cloth are cheesecloth, terry cloth, jersey cloth, cotton flannel, or any other non abrasive material. Carefully wipe along the plexiglass surface being sure to only touch portions of the plexiglass that are still wet from the solution. Focus on particularly dirty spots, taking special care not to scrub or apply too much pressure to the surface. If you have wiped the surface of the plexiglass once and the plexiglass is still dirty, pour the solution over the plexiglass again and repeat the process of gently wiping with a microfiber cloth. Repeat this process as many times as necessary. Do not allow the plexiglass to air dry or sit for too long while it is wet, or else you will leave behind visible water spots. If you find that your plexiglass has dried and retained water spots, just repeat the cleaning process again. Water spots are not anymore difficult to remove than dirt or grime, and should come off easily.
Use a microfiber cloth to prevent surface scratches. Wipe the wet plexiglass with your microfiber cloth. Spray the solution onto the surface and gently wipe any grime that still exists. Wipe the plexiglass until it is dry.