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When you bring your guinea pig home after surgery, let it recover in a calm, quiet area. Place your guinea pig’s cage in an area that does not get a lot of foot traffic from you or other members of your household. If you have other guinea pigs, keep them in a separate cage from the sick guinea pig. If the surgically-removed lump was an abscess or infected cyst, your guinea pig will need antibiotics to prevent post-surgical infection. Because certain antibiotics can make guinea pigs extremely sick, your vet will prescribe a guinea pig-safe antibiotic. Do not purchase antibiotics at a pet store; they may not be safe for your guinea pig.  Guinea pigs typically need at least one round of antibiotics following surgical removal of an abscess. Your vet will determine how long your guinea pig will need antibiotic treatment. To give the antibiotic pill, hold your guinea pig, open its mouth, and put the pill as far back in the mouth as you can. If you can place the pill near the molars, your guinea pig will not be able to spit it back out easily.  Give the full course of antibiotics. Do not stop the antibiotic treatment when your guinea pig starts looking and feeling better. This could lead to the growth of antibiotic-resistant bacteria. After surgery, keep the incision site clean and free of dirt and debris. To clean the incision site, use a clean, slightly damp towel and gently dab around the incision. That area may be a little painful for your guinea pig, so you do not want to use too much pressure. Examine the incision site for signs of infection: redness, swelling, discharge. If the incision site looks abnormal, take your guinea pig to your vet for treatment. Your vet may want to see your guinea pig again after surgery to monitor its recovery. During this follow-up appointment, your vet will examine the incision area, remove sutures (if necessary), and generally assess how your guinea pig is doing.
Place your guinea pig in a quiet environment. Give your guinea pig antibiotics. Clean the affected area. Schedule a follow-up appointment.